set someone's teeth on edge

Example: “The squeak of chalk on the board sets my teeth on edge.”

Origin: Biblical, from Jeremiah 31:29 and Ezekiel 18:2, both using a nearly identical line: "the fathers have eaten sour grapes, and the children's teeth are set on edge." The image is a real physical sensation — the specific bitter, gritty discomfort sour or unripe fruit produces along the teeth and gums — repurposed as a metaphor for suffering the consequences of someone else's actions. The Wycliffe Bible carries the phrase into English as early as 1382, and Shakespeare uses it twice, in Henry IV, Part 1 and The Winter's Tale, by which point it had broadened from that one specific inherited-guilt sense into general irritation or unpleasant sensation, sound included.